Coffee protects cardiovascular health by maintaining the structure of coronary arterial wall intimal collagen

Authors

  • I Dewa Ayu Ayu Susilawati Jember University, Department of Biomedical Science, Faculty of Dentistry, Jember, Indonesia.
  • Suryono Suryono Jember University, Department of Cardiology, Faculty of Medicine, Jember, Indonesia.
  • Purwanto Purwanto Jember University, Department of Biomedical Science, Faculty of Dentistry, Jember, Indonesia.
  • Juris Burlakovs Linnaeus University, Faculty of Health and Life Sciences, Kalmar, Sweden.
  • Abubakar Yaro Institute of Health Sciences & Research, AHRO Scientific Publishing Ltd, 272 Bath Street, Glasgow, Scotland.

DOI:

https://doi.org/10.25186/.v15i.1637

Keywords:

Coffee, Post-harvest, Chemical Composition, Nutrition

Abstract

This study aimed to determine whether coffee consumption affects the structure of coronary arterial wall and protects against coronary artery disease (CAD) in atherosclerotic rat model induced by periodontitis. Rats (n = 21) were divided into three groups (i) Coffee group (periodontitis + coffee), (ii) Periodontitis group (no coffee), and (iii) Control group (no periodontitis, no coffee). A single dose of coffee suspension (representing one cup) was given daily by stomach sondation to the rats in the coffee group. The experiment was conducted for 5 wk. At the completion of the experiment, all of rats were sacrificed. Their hearts containing coronary arteries were removed and analyzed by histochemistry assay. In addition, the serum level of collagen degrading enzymes matrix metalloproteinase–2 (MMP–2) was also analyzed using Enzyme–link immunosorbent assay (Elisa). Results demonstrated that coronary atherosclerotic lesions including atheroma, stenosis, and vascular occlusion were rarely identified in the coffee group. The coronary arterial wall demonstrated relatively symmetrical intima-media thickness (IMT) and the lumen diameter remained adequate for blood flow. The intimal collagen was intact, dense and thick. MMP–2 level was significantly lower (P < 0.05) in the coffee group. In conclusion, coffee maintained the structure of coronary arterial wall particularly the intimal collagen, providing protection against CAD. This might also mediate the vascular resistance against rupture and thrombosis that might precipitate the occurrence of acute coronary syndrome (ACS).

Key words: Acute coronary syndrome (ACS); Coronary artery disease (CAD); Histochemistry; Intima-media thickness (IMT); Matrix metalloproinase-2 (MMP-2).

References

ADEBAYO, J. O. et al. Effect of caffeine on the risk of coronary heart disease. A re-evaluation. Indian Journal of Clinical Biochemistry, 22(1): 29-32, 2007.

AZEVEDO, A. et al. Matrix metalloproteinases are involved in cardiovascular diseases. Basic & Clinical Pharmacology & Toxicology, 115(4):301-314, 2014.

AZIZ, M.; YADAV, K. S. Pathogenesis of atherosclerosis a review. iMedPub Journals: Medical & Clinical Reviews, 2(3):1–6, 2016.

BRODALA, N. et al. Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerotic in normocholesterolemic and hipercholesterolemic pigs. Arterioscler Thromb Vasc Biol, 25(7):1446-1451, 2005.

CÁRDENAS, C.; QUESADA, A. R.; MEDINA, M. A. Anti–angiogenic and anti–inflammatory properties of kahweol, a coffee diterpene. Plos One, 6(8):1-9, 2011.

CORNELIS, M. C.; EL–SOHEMY, A. Coffee, caffeine, and coronary heart disease. Current Opinion in Clinical Nutrion and Metabolic Care, 10(6):745-751, 2007.

GOUGH, P. J.; GOMEZ, I. G.; WILLE, P. T.; RAINES, E. W. Macrophage expression of active MMP–9 induces acute plaque disruption in apoE–deficient mice. Journal of Clinical Investigation, 116(1):59-69, 2006.

HALVORSEN, B. L. et al. A systematic screening of total antioxidants in dietary plants. Journal of Nutrition, 132(3):461-471, 2002.

KAMEDA, K. et al. Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease. European Heart Journal, 24(24):2180-2185. 2003.

KANDASAMY, A. D. et al. Matrix metalloproteinase-2 and myocardial oxidative stress injury: Beyond the matrix. Cardiovascular Research, 85(3):413-423, 2002.

KEMPF, K. et al. Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: A clinical trial. American Journal of Clinical Nutrition, 91(4):950-957, 2010.

LI, L. et al. Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygoes

apolipoprote in e-deficient murine model. Circulation, 105(7):861-867, 2002.

LOPEZ–GARCIA, E. Coffee consumption and risk of chronic diseases: Changing our views. American Journal of Clinical Nutrition, 95(4):787-788, 2012.

MOREIRA, M. E. D. C. et al. Anti–inflammatory effect of aqueous extracts of roasted and green Coffea Arabica. L. Journal of Functional Foods, 5(1):466-474, 2013.

MOSTOFSKY, E. et al. Habitual coffee consumption and risk of heart failure: A dose–response meta–analysis. Circulation: Heart Failure, 5(4):401-405, 2012.

NATELLA, F. et al.. Coffee drinking induces incorporation of phenolic acids into LDL and increases the resistance of LDL to ex vivoxidation in humans. American Journal of Clinical Nutrition, 86(3):604-609, 2007.

NEWBY, A. C. Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation. Matrix Biology, 44-46:157-166, 2015.

OTSUKA, F. et al. Pathology of coronary atherosclerosis and thrombosis. Cardiovascular Diagnosis and Therapy, 6(4)::396-408, 2016.

RAFIEIAN-KOPAEI, M. et al. Atherosclerosis: Process, indicators, risk factors and new hopes. International Journal of Preventive Medicine, 5(8):927-946. 2014.

SAKAKURA, K. et al. Pathophysiology of atherosclerosis plaque progression. Heart, Lung, and Circulation, 22(6):399-411, 2013.

SUSILAWATI, I. D. A. et al. Coronary artery disease in periodontitis rat model. Annals of Tropical Medicine

and Public Health, 23(3A):34-43, 2020.

SHECHTER, M. et al. Impact of acute caffeine ingestion on endothelial function in subjects with and without coronary artery disease. American Journal of Cardiology, 107(9):1255-1261, 2011.

SIASOS, G. et al. Consumption of a boiled greek type of coffee is associated with improved endothelial function: The ikaria study. Society for Vascular Medicine, 18(2):55-62, 2013.

SURYONO, S. et al. Elevated blood serum neutrophil collagenase and NADPH oxidase-1 (NOX-1) in acute

coronary syndrome, Annals of Tropical Medicine and Public Health, 23(3A):171-179, 2020.

TAKAHASHI, M. et al. Preparation of rat serum suitable for mammalian whole embryo culture. Journal of Visualized Experiments, 90:51969, 2014.

TUMMERS, A. M. et al. Serum levels of matrix metalloproteinase–2 as a marker of intimal hyperplasia. Journal of Surgical Research, 160(1):9-13, 2010.

VAN WOUDENBERGH, G. J. et al. Coffee consumption and coronary calcification. The rotterdam coronary calcification study. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(5):1018-1023, 2008.

YALAMEHA, B. Antioxidant therapy to improve or resolve atherosclerosis; new hopes and current trends. Journal of

Nephropharmacology, 8(2):1-4, 2019.

Published

2020-06-16

How to Cite

SUSILAWATI, I. D. A. A.; SURYONO, S.; PURWANTO, P.; BURLAKOVS, J.; YARO, A. . Coffee protects cardiovascular health by maintaining the structure of coronary arterial wall intimal collagen. Coffee Science - ISSN 1984-3909, v. 15, p. e151637, 16 Jun. 2020.

Issue

Vol. 15 (2020): Continuous Publication

Section

Articles

Os direitos autorais dos artigos publicados nesta revista pertencem aos autores, com os primeiros direitos de publicação pertencentes à revista. Como os artigos aparecem nesta revista com acesso aberto, eles podem ser usados ​​livremente, com as devidas atribuições, em aplicativos educacionais e não comerciais.